Amirabad Pathobiology and Virology Laboratory


Mumps is a systemic febrile infection

Date: 3 سال قبل

author: AmirAbad

Mumps Virus
Clinical Manifestations
Mumps is a systemic febrile infection of children and young adults. Swelling of the salivary glands, especially the parotid glands, is characteristic; meningitis is common; and pancreatitis, encephalitis, and hearing loss may occur. In young adults, orchitis or oophoritis is not uncommon.
Classification and Antigenic Type
The single serotype of mumps virus shares antigens with parainfluenza viruses, particularly type 1.
The virus is spread in droplets. Primary infection consists of viremia and involvement of glandular and nervous tissue, resulting in inflammation and cell death.
Host Defenses
Interferon and other initial defenses are followed by specific cellular and humoral immune responses, which confer lifelong immunity.
Mumps is found worldwide. Without extensive vaccination it is endemic in cities with epidemic variations in 2 to 3 years intervals. In rural areas it is intermittent, reappearing there every 5 to 7 years, and may reach epidemic proportions. In temperate climates, the incidence peaks from January to May.
In typical cases, the clinical picture is diagnostic. Atypical cases are diagnosed by isolating the virus in cell culture, or by detecting viral antigen or RNA, and most easily by detecting specific IgM in the first serum sample soon after onset of symptoms or by a rise of IgG antibodies.
Vaccination with live attenuated mumps virus vaccine gives long-lasting immunity, but reinfection may occur.

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