Amirabad Pathobiology and Virology Laboratory


Respiratory Syncytial Virus (RSV)

Date: 2 سال قبل

author: AmirAbad

Respiratory Syncytial Virus (RSV)
Clinical Manifestations
This virus causes upper and lower respiratory tract disease; the latter is most frequent in young children and is also significant in the elderly.
Classification and Antigenic Types
Respiratory syncytial viruses are divided into types A and B
Transmission is by droplets or direct contact. The virus infects the ciliated epithelial cells of the respiratory mucosa and disseminates locally. Disease is caused partly by immunopathologic antibody-dependent cellular cytotoxicity.
Host Defenses
Nonspecific immune defenses, including interferon, are followed by the appearance of secretory and serum antibody and cell-mediated responses. Reinfection occurs, but the frequency and severity of disease decrease with age.
EpidemiologyThis disease is found worldwide; in temperate climates, epidemics occur in winter and early spring and affect mainly infants and young children.
Clinical symptoms are nonspecific; laboratory diagnosis is made by detecting viral antigen, by isolating the virus or by detecting RNA with polymerase chain reaction (PCR), or by detecting a rise in antibody titer or elevated IgM antibodies in a single serum.
There is no vaccine. Aerosolized ribavirin can be used for treatment if necessary. In hospital wards, infected patients may be isolated.

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